Long-term follow-up of 53 cases of combined pancreas-kidney transplantation
10.3760/cma.j.issn.0254-1785.2012.09.004
- VernacularTitle:胰肾联合移植53例术后长期存活的临床观察
- Author:
Changsheng MING
;
Xianzhang LUO
;
Nianqiao GONG
;
Fanjun ZENG
;
Weijie ZHANG
;
Zhishui CHEN
;
Xiaoping CHEN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Pancreas transplantation;
Kidney transplantation;
Rejection;
Long-term survival
- From:
Chinese Journal of Organ Transplantation
2012;33(9):523-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the long-term results after combined pancreas-kidney transplantation at a single-center institution.Methods Fifty-three consecutive patients with insulin-dependent diabetes mellitus and end-stage nephropathy were followed up for more than three years after combined pancreas-kidney transplantation. Immunosuppressive protocol consisted of tacrolimus ( TAC ),mycophenolate mofetil (MMF),and steroids,and antithymocyte globulin or anti-CD25 receptor mAb.The impact of different risk factors was analyzed on long term patient and graft survival.Results The 3-,5- and 8-year survival rate in recipients was 90.1％,89.1 ％ and 80.0％,respectively.The 3-,5- and 8-year survival rate of pancreas grafts was 84.9％,84.8％ and 60.0％,and that of kidney grafts was 83.0％,82.6％ and 53.3％,respectively.Principal causes of death were Infection (n =4),renal failure (n =2),cardiovascular events (n =1 ),and cerebrovascular accident (n =1 ).Graft failure for the pancreas was caused by death with a functioning graft (n =6),rejection (n =2),thrombosis (n =1 ) and pancreatitis (n =1 ).Graft failure for the kidney was due to rejection (n =9),and death with a functioning graft (n =9).Conclusion This series representing the largest experience with long-term follow up in China confirms an excellent long-term survival.Infection,rejection and surgical complication were the major risk factors leading to deaths and graft loss.
