A Case of Addison' s Disease.
- Author:
Yang Hoon CHO
;
Mu Hyoung LEE
;
Choong Rim HAW
;
Ji Hong YOO
- Publication Type:Case Report
- Keywords:
Hyperpigmentation;
Addison's disease
- MeSH:
Addison Disease;
Adrenal Glands;
Adrenocorticotropic Hormone;
Drug Therapy;
Female;
Humans;
Hydrocortisone;
Hyperkalemia;
Hyperpigmentation;
Hyponatremia;
Hypovolemia;
Middle Aged;
Pigmentation;
Plasma;
Solar System;
Thorax;
Tomography, X-Ray Computed;
Weight Loss
- From:Korean Journal of Dermatology
1995;33(6):1148-1153
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Addison's disease is a rare disorder resulted from a chronic deficiency of the adreanl cortical hormone. The clinical manifestations are general weakness, weight loss, hyperpigmentation, hypovolemia with hyponatremia and hyperkalemia. We report a case of Addison's disease in a 60-year-old woman who has experienced slowly progressive weakness, weight loss and generalized cutaneous pigmentation, especially sun exposed area, extensor surface and nail bed for the last, 2 years. On a hormonal assay of the adrenal glands, basal plasma cortisol level was decreased and basal plasma ACTH level was markedly elevated. A chest X-ray showed streaky tuberculous infiltration in left, upper lobe field and adrenal CT scan showed calcific densities of both adrenal glands with nodular enlargement of right adrenal gland. There was a clinical improvement with steroid replacement therapy and anti-tuber- culosis chemotherapy. A nearly normal appearance was obtained after 5 months' treatment.
