Metabolism of amino acids and type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2012.09.020
- VernacularTitle:氨基酸代谢与2型糖尿病
- Author:
Tao CHEN
;
Haoming TIAN
- Publication Type:Journal Article
- Keywords:
Amino acids;
Diabetes mellitus,type 2;
Mammalian target of rapamycin-S6 kinase 1
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(9):773-776
- CountryChina
- Language:Chinese
-
Abstract:
Amino acids (AA) as substrates of gluconeogenesis could promote endogenous glucose production.Some AA can enhance insulin secretion. Recently,many studies have found that some AA can also activate mammalian target of rapamycin-S6 kinase 1 ( mTOR-S6K1 ) pathway,resulting in maintaining pancreatic β cell function on one hand,and on the other hand,inhibiting insulin signal transduction of insulin-sensitive cells and thus causing insulin resistance.
