Expression of macrophage migration inhibitory factor in peripheral blood of patients with Hashimoto's thyroiditis and its clinical significance
10.3760/cma.j.issn.1000-6699.2012.09.012
- VernacularTitle:巨噬细胞移动抑制因子在桥本甲状腺炎患者外周血中的表达及其临床意义
- Author:
Haibo XUE
;
Lei MA
;
Xiuyun WANG
;
Junying LIU
;
Rongjiao ZHOU
;
Li ZHANG
- Publication Type:Journal Article
- Keywords:
Hashimoto's thyroiditis;
Macrophage migration inhibitory factor;
Thyriod gland;
Autoimmunity
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(9):741-743
- CountryChina
- Language:Chinese
-
Abstract:
The levels of macrophage migration inhibitory factor (MIF) in peripheral blood mononuclear cell (PBMC) and serum in patients with Hashimoto's thyroiditis (HT) were detected by real-time PCR and ELISA,respectively.The results revealed that the expression of MIF mRNA in PBMC ( Z =-4.276,P＜0.01 ) and protein level in serum ( Z=-5.358,P＜0.01 ) were increased in HT patients,and positively correlated with thyroid specific autoantibodies and TSH levels.
