Clinical application of hydroxyethyl starch 130/0.4 and sodium chloride injection in patients with early hemorrhagic shock pre-hospital emergency
10.3760/cma.j.issn.1673-4904.2012.24.004
- VernacularTitle:羟乙基淀粉130/0.4氯化钠注射液在早期失血性休克院前急救中的临床应用体会
- Author:
Fuping GUAN
;
Jianguo LI
;
Baoxiang LI
- Publication Type:Journal Article
- Keywords:
Shock,hemorrhagic;
Emergency medical services;
Hetastarch
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(24):9-11
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical efficacy of hydroxyethyl starch 130/0.4 and sodium chloride injection in the treatment of patients with early hemorrhagic shock (HS).MethodsFifty-two cases of early HS were divided into compound sodium chloride injection group(control group,26 cases) and hydroxyethyl starch 130/0.4 sodium chloride injection group (treatment group,26 cases) by random digits table.The clinical effect,mean arterial pressure (MAP),respiratory rate (RR) and heart rate (HR) and serum sodium,serum chloride and prothrombin time(PT) were statistically analyzed before and after treatment for 60 min.ResultsCure rates in treatment group and control group were 84.6％ (22/26) and 38.5％ (10/26),and mortality rates were 15.4％ (4/26) and 61.5％ (16/26),respectively.The difference showed statistical significant(P ＜0.05).MAP,HR and RR in treatment group were obviously improved compared with control group[ (91.5 ± 8.6 )mm Hg( 1 mm Hg =0.133 kPa) vs.(78.5 ± 7.9 )mm H8,( 81.5 ±8.6) times/min vs.( 108.4 ± 10.2) times/min,(21.4 ± 5.3) times/min vs.(25.5 ± 4.6) times/min,P ＜ 0.05 ].Compared with control group,serum sodium,serum chloride and PT in treatment group were no significant difference(P ＞0.05).ConclusionHydroxyethyl starch 130/0.4 and sodium chloride injection could increase the effective circulating blood volume,and improve tissue and organ perfusion and reduce mortality during the patients with early HS.
