Correlation of phosphatase and tensin homolog gene and 1-phosphatidylinositol 3-kinase expression with clinical pathology in rectal cancer
10.3760/cma.j.issn.1673-4904.2012.23.001
- VernacularTitle:直肠癌中磷酸酶和张力蛋白同源基因及磷脂酰肌醇3激酶的表达与临床病理特征的相关性
- Author:
Bin LIU
;
Changlin ZHAO
;
Juan YANG
;
Aimin GONG
;
Junbo YUAN
;
Yongna ZHOU
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
1 -phosphatidylinositol 3 -kinase;
Phosphatase and tensin homolog;
Immunohistochemistry
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(23):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of phosphatase and tensin homolog gene (PTEN) and 1-phosphatidylinositol 3-kinase (PI3K) in rectal cancer and its correlation with clinical pathology.Methods MaxVisionTM immunohistochemical method was used to detect the expressions of PTEN and PI3K in 60 rectal cancer tissues,30 adenoma tissues and 10 normal rectal tissues,and the correlation between the expression levels and its clinicopathologic characteristics was discussed.Results The positive expression rate of PTEN in rectal cancer tissue was significantly lower than that in normal rectal tissue and adenoma tissue [43.3％ (26/60) vs.100.0％ (10/10),93.3％ (28/30),P ＜ 0.05].The positive expression rate of PI3K in rectal cancer tissue was significantly higher than that in normal rectal tissue and adenoma tissue [75.0％ (45/60) vs.30.0％ (3/10),33.3％ (10/30),P ＜ 0.05].The positive expression of PTEN and PI3K were correlated with carcinoembryonic antigen,degree of cell differentiation,TNM stage,lymph node metastasis and distant metastasis(P＜ 0.01 or ＜ 0.05 ),but had no correlation with age,gender,neoplasm location,neoplasm appearance (P ＞ 0.05).The correlated analysis showed that the positive expression of PTEN had negative correlation with PI3K (r =-0.269,P =0.023 ).Conclusions The high expression of PI3K and down regulation of PTEN in rectal cancer are closely related to its invasion and metastasis.There are some values to monitor PTEN and PI3K expression for determining biological behavior of rectal cancer.
