Study on the relationship between blood T-lymphocyte subsets level and hepatitis B virus reactivation

VernacularTitle:血T淋巴细胞亚群水平与乙型肝炎病毒再激活关系的研究
Author: Jianqi ZHUANG ; Xiaodan ZHENG ; Xiaohui ZHENG ; Guangli WANG ; Keqing HUANG
Publication Type:Journal Article
Keywords: Hepatitis B,chronic; T-Lymphocyte subsets; Reactivation
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(19):2897-2898
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between hepatitis B virus reactivation and the level of blood T-lymphocyte subsets.Methods T lymphocyte subsets ( CD3,CD4,CDs ),CD4/CDs level of 40 patients with chronic carriers of hepatitis B virus and 35 patients with hepatitis B virus re-activation were detected by Flow cytometry(Epics XL).Results The hepatitis B virus reactivation in patients with CD3,CD4 and CD4/CDs levels were significantly lower than the chronic hepatitis B virus carriers,The difference between the two groups patients was significant[(71.31 ±5.20)％ vs (68.57 ±6.10)％,(37.82 ±4.90)％ vs (32.12 ±5.93)％,(1.37 ±0.28) vs (1.18 ±0.43 ),all P ＜ 0.05].Conclusion The levels of CD3,CD4 and CD4/CD8 ratio were significantly declined,it may be the one important reason of hepatitis B virus reactivation.