Clinical observation of naloxone for the treatment of neonatal hypoxic-ischemic encephalopathy

VernacularTitle:纳洛酮与脑蛋白水解物联合治疗新生儿缺氧缺血性脑病
Author: Jianzhong LIANG
Publication Type:Journal Article
Keywords: Neonatal hypoxic-ischemia,brain; Naloxone; Brain protein hydrolyzate
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(16):2439-2440
CountryChina
Language:Chinese
Abstract: ObjectiveTo explore effective treatment for moderate and severe neonatal hypoxic-ischemic encephalopathy(HIE).Methods46 cases of moderate to severe HIE were randomly divided into two groups.Control group of 21 cases only accepted the HIE conventional treatment,treatment group,25 cases accepted the HIE conventional treatment and were also given brain protein hydrolyzate combined naloxone treatment,the efficacy of various clinical indicators of the two groups were compared.ResultsThe remarkable effective rate and the total effective rate of the treatment group were significantly higher ( all P ＜ 0.01 ).Consciousness recovery time,recovery time of the original ability,convulsions,muscle tension,recovery time,sucking ability,recovery time,hospital days of treatment group were significantly lower than the control group( P ＜ 0.05 or P ＜ 0.01 ).ConclusionThe effect of naloxone therapy for moderate to severe HIE is significant,and the therapy has high clinical value.