A Case of Adult Neuroblastoma Involving Bone Marrow.
- Author:
Moon Soo KANG
1
;
Jong Weon CHOI
;
Young Chae CHU
;
Chung Hyun NAHM
;
Soo Hwan PAI
Author Information
1. Department of Clinical Pathology, Inha University College of Medicine, Inchon, Korea.
- Publication Type:Case Report
- Keywords:
Neuroblastoma;
Adult;
bone marrow;
Korean
- MeSH:
Abdominal Pain;
Adult*;
Autonomic Nervous System;
Back Pain;
Bone Marrow*;
Drug Therapy;
Hospitals, General;
Humans;
Male;
Neck;
Neoplasm Metastasis;
Neuroblastoma*;
Neurons;
Synaptophysin;
Vimentin
- From:Korean Journal of Clinical Pathology
2000;20(6):543-547
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neuroblastoma, which originates in the sympathetic division of the autonomic nervous system, is the most common extracranial solid malignancy in childhood but rarely occurs in adulthood. Only one case of neuroblastoma has been reported in Korean adult. Authors recently experienced a case of neuroblastoma originating from the retroperitoneal cavity with metastasis to the bone marrow and neck. A 29-year-old male was admitted at Inha University Hospital because of abdominal pain and back pain. The patient had a past history of chemotherapy for retroperitoneal tumor in a general hospital 4 years ago. In biochemical test, neuron specific enolase(NSE) was above 260 ng/mL and urine vanillylmandelic acid(VMA) was positive. Immunohistochemical stainings of bone marrow sections, showed positive reactions for NSE, chromogranin, and synaptophysin, however, revealed negative reactions for MIC2, vimentin, and mixed keratin. Pathologic examination showed the characteristic findings of neuroblastoma. We report this case with a review of literature.
