Relationship between EphA2 and Laryngeal Carcinoma Angiogenesis
10.3760/cma.j.issn.1008-6706.2012.16.003
- VernacularTitle:受体酪氨酸激酶EphA2与喉癌血管生成的关系
- Author:
Yingyao ZHANG
;
Zhina XU
;
Ruihua ZHAI
- Publication Type:Journal Article
- Keywords:
Laryngeal neoplasms;
EphA2;
Microvascular density
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(16):2405-2406
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the relationship between EphA2 and laryngeal carcinoma angionegesis.MethodsImmunohistochemical staining was used to determine the expression of EphA2 and CD34 in 20 normal squamous epithelium tissues and 50 laryngeal carcinoma.The relationship between EphA2 expression and Microvascular density was analyzed bg Spearman correlation and linear regression.ResultsThe MVD in laryngeal carcinoma (54.89 ± 13.67) was significantly higher than that in normal squamous epithelial tissues ( 17.15 ± 5.21 ) ; The EphA2 in laryngeal carcinoma(4.56 ± 1.38) was significantly higher than that in normal squamous epithelial tissues ( 2.49 ± 1.23 ) ( t =16.721,5.847,all P ＜ 0.05 ).There was significant positive linear correlation between EphA2 and MVD in laryngeal squamous cell carcinoma(P ＜ 0.01 ).ConclusionEphA2 may correlate with angionegesis in laryngeal squamous cell carcinoma.
