The protective effect of low molecular dextran combined with salvia miltiorrhiza Injection against kidney damage from contrast agent
10.3760/cma.j.issn.1008-6706.2012.16.011
- VernacularTitle:低分子右旋糖酐和丹参注射液对造影剂肾损伤的保护作用
- Author:
Xuebin XU
;
Feng LI
;
Weijuan ZHANG
;
Jiaolong WANG
;
Ping YE
;
Lin WANG
- Publication Type:Journal Article
- Keywords:
Agents;
Renal damage;
Low molecular dextran;
Danshen injection
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(16):2421-2422
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the protective effect of low molecular dextran combined with salvia miltiorrhiza injection against kidney damage from contrast agent after percutaneous coronary intervention(PCI) and the effect of preventing kidney damage.Methods120 patients who underwent PCI were randomly divided into two groups:the treatment group( low molecular dextran combined with salvia miltiorrhiza treatment) and the control group,each group 60 cases.The control group was given the conventional treatment,and the treatment group was treated with 250ml low molecular dextran and 16ml salvia miltiorrhiza injection for 7d on the basis of conventional treatment.The levels of blood urea nitrogen ( BUN ),serum creatinine ( SCR),β2 microglobulin ( β2-MG),24h urine protein were detected before and 1 d,6d after surgery.ResultsAt one day after application of contrast agent,the levels of BUN,SCR,β2-MG,24h urine protein were increased,and returned to baseline level at 6th day.The levels of BUN,SCR,β2-MG,24h urine protein of the treatment group were significantly lower than those of the control group at 6th day ( P ＜ 0.05 ).ConclusionThe low molecular dextran combined with danshen injection treatment in the perioperative period could effectively reduce the kidney impairment from contrast agent and the incidence of renal insufficiency.
