Clinical observation on the efficiency of intravenous sucrofer combined with erythropoiesis stimulating factor in treatment of patient with refractory renal anemia
10.3760/cma.j.issn.1008-6706.2012.14.027
- VernacularTitle:静脉补充铁剂治疗维持性血液透析患者肾性贫血的疗效观察
- Author:
Haiyan XIANG
;
Lunzhi LIU
- Publication Type:Journal Article
- Keywords:
Anemia,iron-deficiency;
lron compounds;
Erythropoietin,recombinant
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(14):2133-2134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficiency and security of Fe(OH) 3-sncrose-compond combined with erythropoietin on renal anemia.Methods 30 cases of oral iron combined with erythropoietin in the unsatisfactory uremia patients undergoing maintenance hemodialysis,the cases were randomly divided into two groups:the treatment group(n =16) using intravenous sucrose iron 100mg,twice a week,after a total of 1000mg,then l00mg,once 1 -2 weeks;the control group(n =14) continue to oral:ferrous succinate 0.2g,three times everyday,erythropoietin dose was the same in lothgroups for g weeks.Results Hemoglobin was significantly higher(P ＜ 0.01) and hematocrit was significantly higher(P ＜0.01),and serum ferritin significant increased(P ＜0.0l) in sucrose iron treatment group than these of the control group;the patients of treatment group have obviously improved in spirit,appetite,physical and life quality and so on.Sometimes,nausea,vomiting,skin itching were complained lut without significant side effects.While in the control group limited increase in the level of hemoglobin was seen,the majority had nausea,abdominal discomfort,poor appetite.Conclusion The efficiency of intravenous sucmfer combined with erythropoietin in treatment of renal anemia was effective than conventional oral iron combined with erythropoietin and with fewe adverse reactions.
