Clinical significance of detecting ET-1 ,TNF-α and ICAM-1 in peripheral blood of patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1008-6706.2012.16.015
- VernacularTitle:慢性阻塞性肺疾病患者血清内皮素-1、肿瘤坏死因子α和细胞黏附分子-1水平检测
- Author:
Jingyi Lü
;
Hongxia LI
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Endothelin-1;
Tumor necrosis factor-α;
Intercellular adhesion molecule-1
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(16):2429-2430
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical significance of Endothelin-1,Tumor necrosis factor-α and Intercellular adhesion molecule-1 in the patients with chronic obstructive pulmonary disease(COPD).MethodsThe serum samples were prepared from 80 cases with COPD and 30 healthy persons.The levels of ET-1,TNF-α and ICAM-1 were measured by enzyme-linked immunosorbent assay ( ELISA ).Results Levels of ET-1,TNF-α and ICAM-1 in the COPD patients were higher than thosein the healthy cases ( t =4.896,4.621,4.231,all P ＜ 0.05 ).Levels of ET-1,TNF-α and ICAM-1 in the period of AECOPD were higher than those in the cases of the COPD stable time( t =3.346,3.525,3.269,all P ＜0.05 ).ConclusionET-1,TNF-αt and ICAM-1 are involved in airway inflam mation,ET-1,TNF-α and ICAM-1 not only take part in the acute inflammation in COPD,but also closely connected with clinic stages.
