The study on the impact of arrhythmic drugs and arrhythmia duration in cardioversion effect on atrial flutter and atrial fibrillation
10.3760/cma.j.issn.1008-6706.2012.15.011
- VernacularTitle:抗心律失常药及心律失常持续时间对心房扑动、心房颤动转复效果的影响
- Author:
Ping ZHOU
;
Guoning GUO
- Publication Type:Journal Article
- Keywords:
Atrial fibrillation;
Atrial flutter;
Lbutilide;
Propafenone;
Amiodarone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(15):2262-2264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize antiarrhythmic drugs in the treatment of atrial fibrillation and atrial flutter patient different duration,improve the success rate and safety of cardioversion.Methods Make a retrospective analysis of 180 atrial flutter and 180 atrial fibrillation patients data,which were divided into group ibutilide,propafenone group and amiodarone group,Each group were further divided into duration ≤ 3d > 3d,n =30,cardioversion rate was compared after 1.5h,and aralyzed by SPSS16.0.Results Atrial flutter cardioversion rate of ibutilide group ≤3d and 3d was 90% and 83.33% ;propafenone≤3d and 3d were 76.67% and 36.67%,amineamiodarone were 73.33% and 33.33%,cardioversion rate of three groups had no significant difference when atrial flutter duration ≤3d,P > 0.05 ;Ibutilide cardioversion was significantly higher than propafenone,amiodarone when atrial flutter duration > 3d,P <0.05 ;atrial fibrillation cardioversion rate of ibutilide group≤3d and 3d was 80% and 73.33% ;propafenone≤3d and 3d were 43.33% and 26.67%,amineamiodarone were 50% and 36.67%,Ibutilide cardioversion was significantly higher than propafenone,amiodarone when atrial flutter duration ≤3d,P < 0.05; Ibutilide cardioversion was significantly higher than propafenone,amiodarone when atrial flutter duration > 3d,P <0.05 ;the atrial flutter,atrial fibrillation total cardioversion rate of three groups were 81.67%,45.83%,48.33%,ibutilide was significantly higher than propafenone,amiodarone (P < 0.05 ) ;the atrial fluttercardioversion of ibutilide was significantly higher than the atrial fibrillation rate( P < 0.05 ).Conclusion For the duration of ≤ 3d patients,atrial flutter cardioversion rate of ibutilide.oropafenone,and amiodarone did not differ significantly,but the atrial fibrillation cardioversion rate of ibutilide was significantly higher;For the duration of> 3d patients,the atrial flutter and atrial fibrillation cardioversion rate of Ibutilide were higher than propafenone and amiodarone,when choose ibutilide,propafenone,or amiodarone for treating atrial flutter and atrial fibrillation according to individual arrhythmia.