Expression and clinical significance of BRMS1 protein in colon cancer
10.3760/cma.j.issn.1008-6706.2012.13.003
- VernacularTitle:结肠癌组织中乳腺癌转移抑制基因1的表达及意义
- Author:
Guowei LIU
;
Yicai SONG
;
Gang QIU
;
Ping ZHANG
;
Hao FU
- Publication Type:Journal Article
- Keywords:
Colon neoplasms;
Genes,tumor suppressor;
Immunohistochemistry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(13):1925-1926
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of BRMS1 ( breast cancer metastasis suppressorl ) protein in colon cancer.Methods The expression of BRMS1 protein was detected by using EliVision immunohistochemical techniques in 46 cases of colon cancer,and adjacent non cancerous colon tissues.The clinical significance with histopathologic records was aralyzed.Results The expression levels of BRMS1 ( 34.8％ ) in the colon cancer tissues was significantly lower than those of adjacent non cancerous colon tissues( x2 =23.92,P ＜0.01 ).The expression of BRMSl was significantly correlated with tumor size,clinical stage,and lymph node status (x2 =6.02,4.28,4.35,all P＜0.01) ;BRMS1 had no correlation with age,pathological type.Conclusion BRMS1 might synergistically promote the metastasis of colon cancer.Detection of the expression of BRMS1 may be hdpful in determineing the prognosis of colon cancer.
