Observation of the effect of three-dimensional conformal radiation dose fractionation treatment of advanced non-small cell lung cancer
10.3760/cma.j.issn.1008-6706.2012.13.007
- VernacularTitle:三维适形放疗不同剂量分割治疗晚期非小细胞肺癌疗效观察
- Author:
Zongyi GAO
;
Lijuan JIA
;
Yongli LIU
;
Jiangtao LIU
;
Yanli JIA
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Radiotherapy,conformal
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(13):1933-1934
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of three-dimensional conformal radiation dose fractionation treatment of advanced non-small cell lung cancer(NSCLC).Methods 75 NSCLC patients were treated with hypofractionated 3DCRT( observation group),while 73 cases were treated with conventional fractionated radiotherapy (control group).The efficacy and adverse reactions were observed;Survival after treatment were followed up in 1,2,3 years.Lung function was detected before and after radiotherapy treatment,including FVC,FEV1 and CLCO.Results The total effective cases of control group were 47 cases patients ( 64.4％ ),observation group's was 60 cases ( 80.0％ ),total effective rate had statistically significant difference ( x2 =4.50,P ＜ 0.05 ).Survival of control group after treatment in 1,2,3year were 50.7％,24.7％,8.2％,the median survival was 13 months,observation group's were 73.3％,45.3％,20.0％,and 19 months.The survival of these two groups was statistically different (x2 =8.07,6,94,4.22,all P ＜ 0.05 ).The patients blood system side effects of observation group were significantly lower than the control group ( x2 =4.73,P ＜0.05 ) ;acute radiation pneumonia,esophagitis of these two groups had no significant difference in the incidence( P ＞ 0.05 ).Conclusion Hypofractionated 3DCRT treatment of advanced NSCLC had good effect,and its adverse reactions was low,and it was worthy of clinical application.
