The observation of the effecf of docetaxel combination with nedaplatin in the treatment of patients with advanced stage of nonsmall-cell lung cancer

VernacularTitle:多西他赛联合奈达铂治疗晚期非小细胞肺癌疗效观察
Author: Hansheng HUANG ; Lanping YANG
Publication Type:Journal Article
Keywords: Carcinoma; non-small-cell lung; Docetaxel; Nedaplatin
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(12):1773-1774
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of docetaxel combination with nedaplatin in the treatment of patients with advanced stage of normmall-cell lung cancer.Methods 72 patients with advanced stage of nonsmall-cell lung cancer were collected and randomly divided into observation group and control group.Docetaxel combination with nedaplatin was used in observation group and docetaxel combination with cisplatin was used in control group.The curative effect,no advancement time,total live time and adverse reaction were observed in each group.Results The CR rate 8.3％,PR rate 38.9％,total remission rate 47.2％ in observation group had no significant difference with control group.There was no significant difference in no advancement time and total live time between these two groups.The rate of digestive reactions was significantly lower in observation group than in control group ( all P ＜ 0.05 ).Conclusion Docetaxel combination with nedaplatin was an effective method in the treatment of advanced stage of nonsmall-cell lung cancer.The toxic reaction was low and easily to tolerte.