Detection and significance of IL-25 ,eosinophil levels in induced sputum of patients with bronchial asthma

VernacularTitle:支气管哮喘患者诱导痰中白细胞介素-25、嗜酸性粒细胞水平及其意义
Author: Awang ZHOU ; Bin XIA ; Shengwei CHEN ; Jing XU
Publication Type:Journal Article
Keywords: Interleukin-25; Eosinophil; Asthma; Sputum
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(14):2081-2082
CountryChina
Language:Chinese
Abstract: Objective To investigate the roles of interleukin(IL)-25,eosinophils in the occurrence of bronchial asthma.Methods Selected 30 cases of acute episode of asthma(asthma group),and ease a group of 23 cases of asthma treatment(remission group),20 cases of the normal control group.Using the method of gradient ultrasonic atomizing inhalation of Hyperosmotic saline collection of induced sputum specimens,by ELISA method for the determination IL-25 level in induced sputum,count of eosinophils,analysis of correlation between them.Results Group IL-25 in induced sputum of asthma and eosinophil levels[(313.12±75.64)ng/L vs(236.43±57.90)ng/L]were sig-nificandy higher than the control group[(0.386±0.267) × 109/L vs(0.005±0.002) × 109/L],and significantly higher than acute stage in remission stage[(268.63 + 40.19) ng/L,(0.120 + 0.016) × 109/L](P ＜ 0.05).Conclusion IL-25 has an important role in asthma development.It provides a new way of thinking for monitoring and treatment.