Thyroid hormone and tumor angiogenesis
10.3760/cma.j.issn.1673-422X.2012.08.004
- VernacularTitle:甲状腺素与肿瘤血管生成
- Author:
Yangzhi HU
;
Yunlong PAN
;
Xiaoxu ZHAO
;
Li QIN
;
Hui DING
- Publication Type:Journal Article
- Keywords:
Thyroxine;
Neoplasms;
Targeted therapy
- From:
Journal of International Oncology
2012;39(8):573-575
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid hormone is an important hormone for regulating cell differentiation,growth and metabolism.Many studies have shown that thyroid hormone can induce turmor angiogenesis after binding with the integrin ανβ3 receptor at cell surface.Tetraiodothyroacetic acid is the analogue of thyroid hormone,and can inhibit tumor angiogenesis by inhibiting the binding of thyroid hormone with integrin ανβ3.Studying the role of thyroid hormone in promoting tumor angiogenesis may provide a new approach for molecular targeted therapy of tumor.
