Mammalian target of rapamycin inhibitors and tumor therapy
10.3760/cma.j.issn.1673-422X.2012.08.005
- VernacularTitle:哺乳动物雷帕霉素靶蛋白抑制剂与肿瘤治疗
- Author:
Xin LI
;
Zuocheng YANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Antineoplastic agents;
TOR serine-threonine kinases
- From:
Journal of International Oncology
2012;39(8):576-579
- CountryChina
- Language:Chinese
-
Abstract:
Mammalian target of rapamycin(mTOR) inhibitors have the anti-tumor ettect,which have been known early.The traditional mTOR inhibitors include rapamycin and its derivatives,which have been applied in clinical use early.Nowadays,some new small molecule inhibitors such as the PI3K/mTOR duel inhibitor,Torinl,one after another are found to play a unique role in the tumor therapy.
