Relationship between the nutritional status of vitamin A and HBV immune effect in infants
10.3760/cma.j.issn.1008-6315.2012.09.008
- VernacularTitle:婴儿维生素A营养状况与乙型肝炎疫苗免疫效果关系的研究
- Author:
Aiqin MA
;
Xiao PAN
;
Guangcai LI
;
Yongfang JI
;
Qingxiang SHI
;
Zhixu WANG
;
Zhongqing SUN
;
Chunmei ZHONG
;
Yao SHEN
- Publication Type:Journal Article
- Keywords:
Infants;
Vitamin A;
Hepatitis B vaccine;
Immune response
- From:
Clinical Medicine of China
2012;28(9):920-924
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relationship between the status of vitamin A and the level of AntiHBs in infants.Methods One hundred and ninty eight infants met the criteria were recruited into an investigation through local vaccination service.Two milliter venous blood was drawn from each studied child,and the infants' feeding information of successive 72 hours was collected through the 24-hour dietary recall method and 2-day diet records method.The nutrients intakes were analyzed with a NCCW software for calculation.The concentration of serum vitamin A and Anti-HBs was analyzed by HPLC and ECLIA,respectively.The logarithm of anti-HBs concentrations was compared among sub-clinical vitamin A deficiency (87 cases ),suspicious subclinical vitamin A deficient group (51 cases )and normal group (60 cases )and the relationship between the logarithm of anti-HBs concentrations and vitamin A were analyzed.ResultsThere were only 19.7％ of children whose average daily intake of vitamin A reached the 80％ of recommended nutrient intakes(RNI).The incidence rate of vitamin A malnutrition was 67.2％.The serum Anti-HBs GMC was 402.8 U/L The positive rate was 98.0％.There were significant differences on Anti-HBs Ig GMC between Sub-clinical vitamin A deficiency (SVAD) group,suspicious SVAD group and normal group( F =15.88,P ＜ 0.001 ).The correlation coefficient between the level of serum vitamin A and Anti-HBs lg GMC was 0.441 ( P =0.01 ).ConclusionThe results show that the level of serum vitamin A may have influence on the maintenance of an effective anti-HBs level against hepatitis B virus.
