Effects of Zhennao-Ning capsule on cerebral microcirculation
10.3760/cma.j.issn.1673-4246.2012.08.008
- VernacularTitle:镇脑宁胶囊对动物脑微循环的影响
- Author:
Ting WU
;
Hong CHEN
;
Yang LI
;
Hongchen LI
;
Jianning SUN
- Publication Type:Journal Article
- Keywords:
Zhennao-Ning capsule;
Migraine;
Microcirculatory impairment
- From:
International Journal of Traditional Chinese Medicine
2012;34(8):697-699
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Zhennao-Ning capsule on cerebral microcirculation.Methods Cerebral hypoperfusion model of mices was induced by right common carotid arteries ligation method,The cerebral blood flow for 5min was recorded under normal circumstances comand for 30min when modeled,and then calculate the rate of blood flow changes.Microcirculatory impairment model of rats was induced by intravenous injection of high molecular dextran(HMD).The time of the emergence of microcirculatory impairment was recorded.Vascular flow,blood flow pattern and the number of outlets in the same range were recorded.Results The blood flow was significant decrease in the cerebral hypoperfusion model mice,when compared with the control mice.Zhennao-Ning capsules at the dosage of 1500 mg/kg、750 mg/kg treatment could improve the cerebral blood flow of rats at 10,20,and 30 min after modeled (56％,51％,50％ and 42％,49％,51％,respectively,P＜0.01).Zhennao-Ning capsules at the dosage of 600 mg/kg,300 mg/kg could significantly reduce the change of blood flow pattern(P＜0.01),improve vascular flow rate (26％,36％,P＜0.05 or P＜0.01),extend the time of the emergence in the microcirculatory impairment model rat (53％,34％,P＜0.01).Conclusion Zhcnnao-Ning capsules could improve microcirculatory impairment and partly cure the clinical migraine disease.
