Effect of 153Sm-EDTMP combined with ibandranate in the treatment of osseous metastasis of lung cancer
10.3760/cma.j.issn.1008-6706.2012.13.006
- VernacularTitle:153钐-乙二胺四甲基膦酸联合治疗肺癌骨转移骨痛的疗效观察
- Author:
Jianhua HE
;
Wencai YU
;
Qinwen ZENG
;
Shunqiong ZHANG
- Publication Type:Journal Article
- Keywords:
153Sm-EDTMP;
Ibandranate;
Osseous metastasis;
Lung neoplasms;
Radionuclide
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(13):1931-1932
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of 153Sm-EDTMP combined ibandranate in treatment of osseous metastasis of lung cancer.Methods 100 patients with osseous metastasis of lung cancer were randomly divided into two groups.The patients received intervenous drop infusion of 153Sm-EDTMP and ibandranate in treatment group( n =52).The patients received therapy with 153Sm-EDTMP in control group( n =48).The differentces of effect of odynolysis,locomotor activity,improvement of quality of life,recovery of osteolysis,toxical and adverse reaction between two groups were compared.Results The overall response rate 94.2％ in treatment group was significantly higher than that 64.5 ％ in control group( x2 =4.78,P ＜ 0.0.5 ) ;The activity to improve situation 82.6％ in treatment group was significantly higher than that 64.5％ in control group( x2 =4.13,P ＜ 0.05 ) ;The total effective rate of quality of life improve the situation 84.6％ in treatment group was significantly higher than that 62.5％ in control group( x2 =4.58,P ＜0.05 ) ;The side effects had no significant difference between two groups ( x2 =0.345,P ＞ 0.05).Conclusion The treatment of 153Sm-EDTMP combined with ibandranate in the treatment of osseous-metastasis of lung cancer was effective for relieving pain,improvement locomotor activity,improvement of quality of life,recovery of osteolysis.
