Inhibition mechanism of vitamin D in lung cancer
10.3760/cma.j.issn.1673-422X.2012.08.010
- VernacularTitle:维生素D对肺癌的抑癌机制
- Author:
Xiaozheng KANG
;
Keneng CHEN
- Publication Type:Journal Article
- Keywords:
Vitamin D;
Lung neoplasms;
Biochemistry;
Gene expression;
Signal transduction
- From:
Journal of International Oncology
2012;39(8):594-597
- CountryChina
- Language:Chinese
-
Abstract:
In recent years a large number of studies have been conducted to investigate the role of vitamin D and its metabolites in cancer.However,the picture for lung cancer is not clear at the present time.There are three integral components of the vitamin D pathway:the vitamin D receptor(VDR),CYP27B1 and CYP24A1.Besides,vitamin D inhibits the carcinogenesis of lung by indirectly influencing IGF signaling,TGF-β signaling,and Wnt/β-catenin signaling pathway.Their differential expressions in normal lung tissue and lung cancer offer clues and lay the foundation for research of the inhibitory function in lung cancer pathogenesis.
