The association between single nucleotide polymorphism analysis of tryptophan hydroxylase isoform gene rs11178997 and depression and suicidal behavior
10.3760/cma.j.issn.1674-6554.2012.08.004
- VernacularTitle:色胺酸羟化酶2基因rs11178997多态性与汉族人群单相抑郁及自杀行为的关联性分析
- Author:
Yanjie YANG
;
Lin WANG
;
Jingsong MA
;
Xiuxian YANG
;
Xiaohui QIU
;
Zhengxue QIAO
;
Sijia ZHANG
;
Na ZHAO
;
Jiag SHI
;
Nan NING
- Publication Type:Journal Article
- Keywords:
Depression;
Suicidal behavior;
TPH2 gene;
Single nucleotide polymorphism
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(8):684-686
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relationship between single nucleotide polymorphism analysis of a novel tryptophanhydroxylase isoform(TPH2)gene rs11178997and depression,and suicidal behavior.MethodsThe specimens of peripheral blood were collected from Chinese Northern 300 depression and 300 controis.The amplification of TPH2 gene rs11178997 was executed by realtime-polymerase chain reaction (realtime-PCR),and analyzed by directed sequencing.And the association between the polymorphisms of TPH2 gene and depression and suicidal behavior was analyzed with SPSS 17.0.ResultsThe genotypic frequencies of the SNPs did not deviate from Hardy-Weinberg equilibrium both in patient and control groups (P ＞ 0.05 ).Compared with control group,significant difference of genotypes and alleles of TPH2 gene rs1 1178997 single nucleotide polymorphism had been found in patient group (75.7％ vs 39.7％,6.0％ vs 1.3％,18.3％ vs 1.3％ ; P＜ 0.05 for all),and the AA genotype frequency of rsl 1178997 was significantly higher in patients.Meanwhile there were not significant differences between genotypes of TPH2 gene rs11178997 and suicide behavior in patient group.Suicidal behavior of depression patients in allele genotypes was higher than nonsuicide behavior of depression patients (P ＞0.05).ConclusionTPH2 gene rs4570625 single nucleotide polymorphisms have association with the susceptibility of depression.
