P2X7 receptors in the genesis and development of breast cancer
10.3760/cma.j.issn.1673-422X.2012.08.009
- VernacularTitle:P2X7受体与乳腺癌的发生和发展
- Author:
Chao TAN
;
Li HAN
- Publication Type:Journal Article
- Keywords:
Receptors,purinergic P2;
Breast neoplasms;
Adenosine triphosphate
- From:
Journal of International Oncology
2012;39(8):591-593
- CountryChina
- Language:Chinese
-
Abstract:
P2X7 receptors,belonging to purinergic P2 receptor family,are ATP-gated cation channels,which can choose the bivalent cations freely.P2X7 receptors join in cell signal conduction and the excretion of the cytokines and other physical functions.In recent years,researchers have discovered P2X7 receptors mediate the cells to live and grow by increasing oxidation and phosphorylation and intracellular ATP reserve.In breast cancer,the P2X7 receptors express abnormally,and can activate the MAPK lied in cytoplasm.The phosphorylated MAPK enter the nucleus and activates a series of protein kinases,and then affects the genesis and development of breast cancer.
