MELD-Na score combined with serum cholesterol and endotoxin concentration on the evaluation of the decompensated liver cirrhosis prognosis
10.3760/cma.j.issn.1008-6315.2012.09.012
- VernacularTitle:终末期肝病血清钠评分联合血清内毒素和胆固醇对肝硬化失代偿期患者预后的判断价值
- Author:
Ling FU
;
Xuechun YU
;
Jingwu DONG
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Cholesterol;
Endotoxin;
MELD-Na
- From:
Clinical Medicine of China
2012;28(9):933-936
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognosis of the decompensated liver cirrhosis by means of MELD-Na score combined with serum cholesterol and endotoxin concentration.MethodsData of 156 hospitalized patients with decompensated liver cirrhosis was retrospectively analyzed.Patients were divided into survival and death group according to follow-ups at 6 months,12 months and 24 months.MELD-Na score was made among 156 patients by detecting relevant indicators.Serum cholesterol and cholesterol levels were measured,too.The relationship between decompensated liver cirrhosis prognosis and MELD-Na score combined with serum cholesterol and endotoxin concentration was analyzed.ResultsNinteen patients died at the follow-up for 6 months.Fifty nine patients died at the followe-up for 12 months.Seventy seven patients died at the follow-up for 24 months.There was significant difference on MELD-Na score,endotoxin concentration and serum cholesterol between the survival group and the death group (t =-9.68,-9.22,11.4,-4.65,-19.60,16.20,-20.0,-18.7,17.3,respectively,P ＜0.05).The best critical value of MELD-Na score to predicate death in patients with decompensated liver cirrhosis was 32 points.The risk of death would rise if MELD-Na score increased.The best critical value of plasma endotoxin to predicate death in patients with decompensated liver cirrhosis was ≥ 12 ng/L.The best threshold value of serum cholesterol to predict death in patients with decompensated liver cirrhosis was ≤ 1.70 mmol/L.ConclusionMELD-Na score,serum cholesterol and serum endotoxin were of higher prognostic value to judge the prognosis of patients with decompensated liver cirrhosis.
