Effects of glucose excursion on cognitive function in aged type 2 diabetes
10.3760/cma.j.issn.0254-9026.2012.08.002
- VernacularTitle:血糖波动对老年2型糖尿病患者认知功能的影响
- Author:
Xiaoyan ZHANG
;
Yuan ZHONG
;
Ya MIAO
;
Jiehua ZHU
;
Hong YAN
;
Jun JIN
;
Beiyun WANG
;
Tingjun HU
- Publication Type:Journal Article
- Keywords:
Diabetes,Type 2;
Cognitive disorders;
Glucose metabolism disorders
- From:
Chinese Journal of Geriatrics
2012;31(8):646-648
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between glucose excursion and cognitive function in aged type 2 diabetes. Methods A total of 248 aged type 2 diabetes were recruited in this study,all of them wore continuous glucose monitoring system (CGMS) for 3 d to evaluate the glucose excursion including mean amplitude of glycemic excursions (MAGE) which was used for assessing intra-day glycemia variability,and mean daily difference (MODD) which represented day-to-day glycemic variability.During the period of CGMS monitoring,all subjects accepted mini mental status examination (MMSE) for evaluating cognitive function.The relationships of MAGE and MODD with performance on cognitive tests were assessed. Results The over intra-day glucose excursion group had lower MMSE score than the narrow intra-day glucose excursion group[(24.25±6.75)vs.(25.97±0.47),P=0.025].The MMSE score was decreased in over day-to-day glucose excursion group compared with the narrow day-to-day glucose excursion group [(24.21 ± 6.47) vs. (26.01 ± 5.49),P =0.019]. A statistically significant association was observed between MAGE and the score of MMSE(r=- 0.308,P＜0.001),and between MODD and MMSE(r=-0.226,P =0.001).Conclusions Glucose excursion may affect cognitive function in aged type 2 diabetes.The over glucose excursion decreases the score of MMSE.
