Molecular mechanism of flavonoids for preventing radiation-induced lung injury
10.3760/cma.j.issn.1673-422X.2012.08.008
- VernacularTitle:黄酮类化合物预防放射性肺损伤的分子机制
- Author:
Jian CHENG
;
Lingling KONG
;
Hongjun LI
;
Baosheng LI
- Publication Type:Journal Article
- Keywords:
Flavones;
Radiation pneumonitis;
NF-kappa B
- From:
Journal of International Oncology
2012;39(8):588-590
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced lung injury is a common complication of thoracic cancer radiotherapy.A lot of animal experiments and clinical studies have shown that ionizing radiation-induced lung injury is a complex process regulated by a variety of cytokines.The transcription factors including nuclear factor κB,MAPK and activator protein-1 are involved in radiation-induced lung injury by regulating the synthesis of a variety ofinflammatory proteins.The flavonoids play a role in radiological protection by blocking the pathway of nuclear factor kB and activator protein-1.
