The comparison of cognitive potential P300 in major depressive disorder between with and without family history
10.3760/cma.j.issn.1674-6554.2012.08.009
- VernacularTitle:有无家族史抑郁症患者认知电位P300的比较
- Author:
Dongmei YAN
;
Yan REN
;
Kewen WU
;
Zixuan ZHOU
;
Jiao JIA
;
Xia LIU
;
Hong YANG
- Publication Type:Journal Article
- Keywords:
Depression;
Recurrent;
Cognitive potential;
P300
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(8):699-701
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the character of cognitive potential P300 in major depressive disorder ( MDD ) patients between with and without family history and compare the cognitive function between them.MethodsSixty-seven MDD patients with family history and sixty-seven MDD patients without family history were assigned to research group,sixty-seven healthy volunteers were assigned to control group,and ERP P300 detections were conducted in all subjects.Results①To compare with control group ( ( 189.33 ± 51.13 ) ms) and MDD without family history group( ( 193.55 ± 40.01 )ms),the N2 latency was prolonged more significantly in MDD with family history group ( ( 208.40 ± 33.05 ) ms ) (P ＜ 0.05 ).②Compared with control group ( ( 3.38 ± 5.52 ) μV ),the N2 amplitude was decreased more significantly in MDD without ( ( 2.47 ± 1.87 ) μV ) and with family history ( ( 2.36 ± 2.10) μV ),(P ＜ 0.05 ).ConclusionThere is an obvious cognitive function damaged in the MDD patients with and without family history and the MDD patients with family history are more serious.
