Clinical report on nonmyeloablative autologous peripheral blood stem cell transplantation for systemic lupus erythematosus by using different conditioning regimens
10.3760/cma.j.issn.1007-7480.2012.08.007
- VernacularTitle:不同预处理方案自体非清髓性造血干细胞移植治疗系统性红斑狼疮的临床观察
- Author:
Jingbo XU
;
Wenzheng PANG
;
Xuegang LI
;
Feng XIE
;
Shuping ZHONG
;
Jiangnan REN
;
Lijun HOU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Stem cell eransplantation;
Transplantation conditioning
- From:
Chinese Journal of Rheumatology
2012;16(8):527-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy and safety of two different conditioning regimens in nonmyeloablative autologous peripheral blood stem cell transplantation (NAST) for the treatment of systemic lupus erythematosus (SLE).Methods Different conditioning regimens were used in two groups:cytarabin combined cyclophosphamide in group 1 and ATG combined cyclophosphamide in group 2.Different recovery time of leucocytes,neutrophils and platelets in the two groups were compared.Statistical analysis were carried out by paired t-test.Results The mean time for peripheral leucocytes reaching 1.0×109/L,neutrophils getting up to 0.5×109/L,platelet raising to 100×l09/L and hemoglobin rising to 120 g/L in group 1 were [(7.2±1.3),(8.0±1.5),(10.5±1.4),(22.1±2.3)days] and [(10.4±2.1),(12.0±1.9),(19.3±2.1),(28.1± 2.4)] days in group 2.The difference was statistically significant (P＜0.01).CD4+ cell count and the ratio of CD4+/CD8+ of pre- and pro-NAST was changed.No significant differences were observed in the two groups.Conclusion For the sake of safety and hematopoietic reconstitution,we recommend cytarabin combined cyclophosphamide as the preferred conditioning regimen.
