The significance of serum concentrations of transforming growth factor-β1 and bone morphogenetic protein-4 in patients with rheumatoid arthritis and interstitial lung disease
10.3760/cma.j.issn.1007-7480.2012.08.011
- VernacularTitle:类风湿关节炎合并间质性肺病患者血清中转化生长因子-β1骨形成蛋白-4检测及其意义
- Author:
Jun SHENG
;
Tihong SHAO
;
Dan XUAN
;
Tongjun MAO
;
Zhi LI
;
Jinming LU
;
Liang XU
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Lung diseases,interstitial;
Transforming growth factor beta;
Bone morphogenetic protein-4
- From:
Chinese Journal of Rheumatology
2012;16(8):545-548
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the serum levels of transforming growth factor (TGF)-beta 1,bone morphogenetic protein (BMP)-4 in patients with rheumatoid arthritis (RA) and RA with interstitial lung disease (RA-ILD).Methods Twenty-eight RA-ILD patients,32 patients with RA but without ILD and 20 normal controls were enrolled.The RA-ILD group was further divided into early group and late group.All the observed subjects were analyzed using enzyme linked immunosorbent assay (ELISA) for the determination of serum TGF-β1 and BMP-4 levels.The relationship between the serum levels of TGF-β1,BMP-4 and laboratory examinations were investigated.Comparisions between groups were tested by one-way ANOVA analysis and ttest.Correlation of indexs were observed by Spearman method.Results Patients in the RA-ILD group were older than RA group in disease onset age,in addition,patients with ILD had better joint function and higher serum rheumatoid factor titers.The occurrence time of interstitial lung disease was 2-6 years after the onset of arthritis,with an average time of (3.0±1.2) years.The TGF-β1 levels in the RA-ILD group were slightly higher,but not statistically significant than other groups (P＞0.05).The TGF-β1 serum levels in the early RA-ILD patients were significantly increased than those of the late RA-ILD group and the RA group.BMP-4 levels in patients with RA-ILD group were less than RA without ILD group and healthy control group,and the difference was statistically significant (P＜0.05).BMP-4 level in early RA-ILD group was significantly decreased than those of the late RA-ILD group and RA group.No correlation between the serum BMP-4,TGF-β1 level (P＞0.05) no assay result correlated with laboratory parameters including ESR,CRP,RF and anti-CCP antibodies (P＞0.05).Conclusion TGF-β1 serum levels are increased and BMP-4 levels are decreased in early RA-ILD patients.The serum levels of TGF-β1 and BMP-4 may be indicatior for asymptomatic ILD and reflect disease progression.
