Epidemiologic study of the distribution of urate crystals in patients with gout by foot dual-energy CT
10.3760/cma.j.issn.1007-7480.2012.08.014
- VernacularTitle:痛风患者足踝双能CT尿酸盐结晶沉积特点分析
- Author:
Lindi JIANG
;
Yi ZHOU
;
Ying SUN
;
Yuqin DING
;
Jianjun ZHOU
;
Mengsu ZENG
;
Hejian ZOU
- Publication Type:Journal Article
- Keywords:
Gout;
Dual-energy CT;
Urate crystal
- From:
Chinese Journal of Rheumatology
2012;16(8):556-559
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of urate crystal as well as the relationship bet ween the features of the crystals and the attacks of joint pain and/or swollen by foot dual-energy CT.Methods Eight-four patients (68 were diagnosed as gout, 11 were patients with hyperuricemia and 5 were diagnosed as other types of arthritis) who recently experienced foot swelling and/or pain were enrolled and all of them were performed foot dual-energy CT.The relationship between the features of the urate crystals and the attacks of gouty arthritis was determined by Chi test and the potential risk factors were identified by Logistic multiple regression analysis.Results Two hundred and seventyeight urate crystal depositions were found in 68 gout patients,and the most common deposition sites were the distal parts of the first toe(18.2％),the first metatarso-phalangeal joint ( 16.8％ ),calcaneus ( 17.5％ ),the lower end of tibia ( 11.8％ ).Furthermore,patients with the urate crystals deposited in the first metatrasophalangeal joint or the lower end of of tibia were more likely to experience acute episodes of gout attack (P＜0.01,P＜0.05 respectively).In addition,the shape,size and quantity of urate crystals also affected episodes of acute attack of gout.Conclusion Dual-energy CT,which is a non-invasive method,could clearly reveal urate crystal depositions and is helpful for the diagnosis and follow-up of patients with gout.The location,shape,size and quantity of urate crystals and soft tissue swelling,bone erosion may affect the acute attack of gout.
