In vitro activity of seven imidazole antifungals including luliconazole against common Candida species

Qing Cai; Le Wang; Rong Zeng; Suquan HU; Wei Chen; Yongnian Shen; Guixia Lü; Weida Liu

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In vitro activity of seven imidazole antifungals including luliconazole against common Candida species

VernacularTitle:卢立康唑等七种咪唑类抗真菌药物对常见念珠菌的体外活性检测
Author: Qing CAI ; Le WANG ; Rong ZENG ; Suquan HU ; Wei CHEN ; Yongnian SHEN ; Guixia Lü ; Weida LIU
Publication Type:Journal Article
Keywords: Candida; Microbial sensitivity tests; Antifungal agents
From: Chinese Journal of Dermatology 2012;45(8):538-540
CountryChina
Language:Chinese
Abstract: Objective To evaluate the in vitro activity of seven imidazole antifungals against clinical isolates of common Candida species.Methods According to the Clinical and Laboratory Standards Institute (CLSI) microdilution method M27-A3,the in vitro activity of luliconazole,ketoconazole,miconazole,econazole,clotrimazole,sertaconazole and bifonazole was determined among 183 clinical isolates belonging to 5 species of Candida.Results The minimal inhibitory concentration range was 0.03-8 (geometric mean:0.067) mg/L for ketoconazole,0.03-16 (geometric mean:0.071 ) mg/L for miconazole,0.03-8 (geometric mean:0.207) mg/L for econazole,0.03-8 (geometric mean:0.061 ) mg/L for clotrimazole,0.03-16 (geometric mean:0.187) mg/L for sertaconazole and 0.03 -＞16 (geometric mean:1.050) mg/L for bifonazole. Luliconazole exhibited a superior activity against the 5 species of Candida in vitro,with the MIC range being 0.03-8 mg/L,geometric mean MIC 0.087 mg/L,MIC50 0.06 mg/L and MIC90 0.5 mg/L,respectively.However,some Candida isolates were identified to be relatively insensitive to these tested antifungals,including luliconazole.Conclusion All the tested imidazole antifungals,except for bifonazole,show an excellent activity against Candida species in vitro,but there exist a few Candida strains with relative insensitivity.