New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences.
- Author:
Olga PENAGARIKANO
1
Author Information
- Publication Type:Review
- Keywords: Autism; ASD; Pharmacotherapy; Treatment; Social behavior; Repetitive behavior
- MeSH: Animals; Autistic Disorder*; Child; Autism Spectrum Disorder*; Drug Therapy; Genetics, Medical; Humans; Mice; Phenotype; Population Characteristics; Social Behavior; Stereotyped Behavior
- From:Experimental Neurobiology 2015;24(4):301-311
- CountryRepublic of Korea
- Language:English
- Abstract: Autism spectrum disorder (ASD) is characterized by impairment in two behavioral domains: social interaction/communication together with the presence of stereotyped behaviors and restricted interests. The heterogeneity in the phenotype among patients and the complex etiology of the disorder have long impeded the advancement of the development of successful pharmacotherapies. However, in the recent years, the integration of findings of multiple levels of research, from human genetics to mouse models, have made considerable progress towards the understanding of ASD pathophysiology, allowing the development of more effective targeted drug therapies. The present review discusses the current state of pharmacological research in ASD based on the emerging common pathophysiology signature.
