Significance of stem cell transcription factor Nanog expression in hepatocellular carcinoma

VernacularTitle:干细胞转录因子Nanog在肝细胞癌中的表达及意义
Author: Xiewu QIU ; Conghui YU ; Junbo YAO ; Chao NAI ; Yuwang TIAN
Publication Type:Journal Article
Keywords: Carcinoma,hepatocellular; Transcription factors Nanog
From: Chinese Journal of General Practitioners 2012;11(8):598-600
CountryChina
Language:Chinese
Abstract: From August 2007 to April 2011,hepatocellular carcinoma (HCC) (n =40),paraHCC tissues (n =10),seminoma (n =10) and cavernous hemangioma (n =10) were selected.And the method of immunohistochemical streptavidin-perosidase was applied to detect the protein expression of Nanog.The expression ratios of Nanog were 17/40 (42％),1/10,0/10 and 5/5 in HCC,para-HCC tissues,seminoma and cavernous hemangioma respectively.Its expression showed no significant correlation with the patient gender,age,serum alpha fetoprotein (AFP),hepatitis B surface antigen (HBsAg),differentiation,Child grade and TNM stage ( P ＞ 0.05 ).It may be used as a surface marker of liver cancer stem cell.