Correlation between B-type natriuretic peptide and fibrinogen in the elderly patients with coronary heart disease
10.3760/cma.j.issn.0254-9026.2012.08.017
- VernacularTitle:老年冠心病患者脑利钠肽与纤维蛋白原的相关性研究
- Author:
Jie GENG
;
Shutao CHEN
;
Hongliang CONG
;
Lin WANG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Natriuretic peptide,brain;
Fibrinogen
- From:
Chinese Journal of Geriatrics
2012;31(8):697-700
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between B-type natriuretic peptide (BNP) and fibrinogen (Fib) in the elderly patients with coronary heart disease (CHD). Methods According to the level of BNP,325 subjects aged more than 65 years were divided into four groups,BNP:≤32.4ng/Lgroup,32.5～62.3 ng/Lgroup,62.4～162.5 ng/Lgroup,＞162.5 ng/L group.The levels of left ventricular ejection fraction (LVEF),left ventricular end-diastole dimension (LVEDD) and Fib were compared among the groups. Results With increasing BNP level,the LVEF was gradually decreased [(63.3±8.2)％,(59.6±7.4)％,(57.9±9.7)％,(55.2±10.6)％] and the level of LVEDD was increased[(50.5±4.7)mm,(51.4±5.4)mm,(52.8±5.7)mm,(54.2±5.9)mm ;F=11.54,6.76,both P＜0.01],the level of Fib was enhanced [(3.4±0.7)g/L,(3.7±0.8)g/L,(3.8±1.1)g/L,(4.2±1.0)g/L; F=8.02,P＜0.01].The level of BNP had positive correlation with Fib (r=0.25,P＜0.01). Multi-linear regression analysis showed that Fib and LVEF were influencing factors of BNP (t =2.92, - 3.15, both P ＜ 0.01 ). Conclusions The BNP level is helpful to diagnose heart failure and assess heart function.There is an association between BNP and Fib level.
