Homocysteine and ischemic stroke
10.3760/cma.j.issn.1673-4165.2012.07.010
- VernacularTitle:同型半胱氨酸与缺血性卒中
- Author:
Sheng HE
;
Kaifu KE
- Publication Type:Journal Article
- Keywords:
Homocysteine;
Stroke;
Brain Ischemia;
Atherosclerosis;
Vitamin B12;
Vitamin B6;
Folic Acid
- From:
International Journal of Cerebrovascular Diseases
2012;20(7):532-537
- CountryChina
- Language:Chinese
-
Abstract:
Homocystine (Hcy) is an important intermediate product of amino acid metabolism.It is dual-regulated by both gene and environmental factors.The key enzyme of metabolic reaction is dependent on vitamin B class.The studies of in vitro experiment and animal models have demonstrated that Hcy may aggravate atherosclerosis by reducing the nitric oxide activity,enhancing intracellular oxidative stress,and promoting thrombosis,etc.Epidemiological studies have also demonstrated that hyperhomocystinemia (HHcy) is an independent risk factor for atherosclerosis.However,large randomized controlled trials have failed to confirm the close correlation between HHcy and ischemic stroke.By supplementing vitamin B class to decrease the Hcy level is still controversial in the primary and secondary prevention.The therapeutic dose of vitamin B class may be unable to obtain additional benefits in patients with ischemic stroke.
