Clinical characteristics and treatment of ceftriaxone-associated postrenal acute renal insufficiency
10.3760/cma.j.issn.1000-6702.2012.08.004
- VernacularTitle:头孢曲松相关急性肾后性肾功能不全的临床特点和治疗
- Author:
Zhen CHEN
;
Zheng LIU
;
Hongjuan SHI
;
Cong LI
;
Ying ZHAN
- Publication Type:Journal Article
- Keywords:
Ceftriaxone;
Renal insufficiency,acute;
Treatment outcome
- From:
Chinese Journal of Urology
2012;33(8):570-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and treatment of acute postrenal acute renal dysfunction associated with ceftriaxone.Methods Twenty-five cases of the ceftriaxione-associated acute postrenal renal insufficiency were reviewed.There were 16 males and 9 females,mean age 28years.The serum contents of BUN and Cr were ( 18.6 ± 7.0) mmol/L and (635.5 ± 248.7 ) μmol/L,respectively.All patients were divided into two groups depending on the therapy:11 patients accepted the drug therapy (alkalinization of the urine,antispasmodic,etc) and 14 patients accepted the intraureteral cannula.The clinical characteristics and the treatment effect were compared between the 2 groups.Results The patients of the intraureteral cannula group ( 1.4 ± O.7 d) went to hospital earlier than the drug therapy group (3.0 ± 1.4 d) ( P =0.045 ) after the symptom of oliguria or anuria appeared.There were no significant differences in serum creatinine,urea nitrogen,and the age between the 2 groups ( P ＞ 0.05 ).All the patients were cured after treatment.There were no significant differences in recovery time (2.9 ± 1.1 d and 3.2 ± 1.2 d,P =0.963) and hospitalization time (7.0 ±2.3 d and 5.9 +3.9 d,P =0.568) between the 2 groups.Conclusions The acute renal failure associated with ceftriaxone should have high attention.The prompt medical attention,including the intraureteral eannula and the drug therapy,can both achieve the satisfying curative effect.
