A noninvasive diagnostic model of liver fibrosis using serum markers in primary biliary cirrhosis
10.3760/cma.j.issn.0578-1426.2012.08.011
- VernacularTitle:原发性胆汁性肝硬化无创性肝纤维化诊断模型的建立
- Author:
Jiali MA
;
Rui WANG
;
Fukui ZHANG
;
Jidong JIA
;
Xiaojuan OU
;
Tao ZHANG
;
Yu WANG
;
Weijia DUAN
;
Xinyan ZHAO
;
Hong YOU
;
Hong MA
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis,biliary;
Noninvasive diagnosis;
Model;
Liver fibrosis
- From:
Chinese Journal of Internal Medicine
2012;51(8):618-622
- CountryChina
- Language:Chinese
-
Abstract:
Objective To verify and assess diagnostic value of noninvasive diagnostic model of liver fibrosis in primary biliary cirrhosis (PBC) based on conventional laboratory markers.Methods Seventythree patients with PBC diagnosed by liver biopsy between January 2003 and June 2011 in Beijing Friendship Hospital,Capital Medical University were recruited in this study.Correlation analysis and logistic regression analysis between the conventional laboratory markers and histology stages were assessed.A liver fibrosis diagnostic model was established based upon aforementioned biomarkers and verified by its sensitivity and specificity for predicting the liver fibrosis.Results The predictive model ( H index) consisting of five conventional laboratory markers,i.e.,platelet count,serum cholinesterase,albumin,HDL-C and prothrombin time activity,could predict advanced fibrosis ( stages Ⅲ-Ⅳ ) with an AUCROC of 0.861.The sensitivity of predicting the absence of advanced fibrosis using H index ＜ - 2.20 was 96.6％ and the specificity of predicting the presence of advanced fibrosis using H index ＞ 0.41 was 93.2％.Conclusion The established noninvasive diagnostic model consisting of five laboratory markers could accurately distinguish pathological changes of early stage PBC ( stages Ⅰ - Ⅱ ) from advanced stage PBC ( stages Ⅲ-Ⅳ).
