Comparative study on the clinical outcome following different doses of amphotericin B liposome in the treatment of patients with invasive pulmonary fungal infections after renal transplantation
10.3760/cma.j.issn.0254-1785.2012.08.010
- VernacularTitle:常规与小剂量两性霉素B脂质体治疗肾移植受者肺部真菌感染的研究
- Author:
Ding LIU
;
Yongguang LIU
;
Xianghua SHI
;
Ming ZHAO
;
Ying GUO
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Pulmonary infections,fungal;
Invasive;
Amphotericin B liposome;
Low doses
- From:
Chinese Journal of Organ Transplantation
2012;33(8):481-484
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the clinical effectiveness and adverse effects following low doses versus traditional doses of amphotericin B liposome (L-AmB) in the treatment of patients with invasive pulmonary fungal infections (IPFI) after renal transplantation.MethodsA total of 26 postrenal transplantation patients with IPFI between Jan. 2005 and Mar. 2011in Zhujiang hospital received L-AmB treatment identified low doses group (0.2-0.5 mg·kg-1·d-1,n =19) or traditional doses group (1-5 mg· kg-1,d-1,n =7) were reviewed.ResultsThe treatment duration in low doses group and traditional doses group was 20.3 +12.7 and19.3 ±13.2 days respectively (P＞0.05).The effective rate in low doses group and traditional doses group was 84.2％ and 57.1％ respectively (P＞0.05).The overall dosage was significantly less in the low doses group (414.7 ± 241.7 mg) than in the traditional doses group (1158.8 ± 928.0 mg) (P＜0.05).The incidence of adverse effect was significantly lower in the low doses group than in the traditional doses group (21.1％ vs.85.7％,P＜0.05).ConclusionThe effectiveness of low doses of L-AmB protocol in the treatment of IPFI postrenal transplantation patients was similar to that of traditional doses of L-AmB protocol,but the incidence of adverse effects in low doses of L-AmB protocol was significantly lower.
