Effects of telmisartan on the serum levels of homocysteine and transforming growth factor-β 1 in patients with early diabetic nephropathy

VernacularTitle:替米沙坦对早期糖尿病肾病患者血浆同型半胱氨酸及转化生长因子β1水平的影响
Author: Peng LIU ; Debao WANG ; Fengmei ZHANG ; Yingying CHEN
Publication Type:Journal Article
Keywords: Diabetic nephropathies; Cysteine
From: Chinese Journal of General Practitioners 2012;11(8):611-613
CountryChina
Language:Chinese
Abstract: Sixty patients with early diabetic nephropathy (DN) and normal blood pressure were randomly divided into telmisartan treatment and control groups.And the blood biochemical parameters,urinary albumin excretion rate (UAER),the serum levels of homocysteine (HCY) and transforming growth factor-β1 (TGF-β1) were measured at both pre- and post-treatment of 24 weeks.After treatment,the levels ofUAER,HCY [(61 ±26) vs.(98±38) mg/L,(11.70 ±2.86) vs.(14.4±2.8) μmol/L (P＜ 0.01 ) ]and homeostasis model of insulin resistance index,TGF-β1 [ ( 3.17 ± 0.66) vs.( 3.60 ± 0.87 ),(66 ± 14) vs.(77 ± 17 )U/L respectively (P ＜ 0.05 )]in the telmisartan group were significantly lower than those in the control group.It indicated that telmisartan could improve the insulin sensitivity,significantly decrease the serum levels of HCY and TGF-β1,reduce UAER and exert kidney protection effects in the patients with early DN.