Guanmaining tablet in the treatment of acute coronary syndrome and its intervention of brain natriuretic peptide, high sensitivity C reactive protein
10.3760/cma.j.issn.0254-9026.2012.08.010
- VernacularTitle:冠脉宁片治疗急性冠状动脉综合征的疗效及其对血脑钠肽C反应蛋白的影响
- Author:
Jianzhong LU
- Publication Type:Journal Article
- Keywords:
Acute Coronary Syndrome;
Natriuretic peptide,brain;
C reactive protein;
Atherosclerosis
- From:
Chinese Journal of Geriatrics
2012;31(8):676-678
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of Guanmaining tablet in the treatment of acute coronary syndrome (ACS) and its intervention of brain natriuretic peptide (BNP),high sensitivity C reactive protein (hs-CRP) and carotid atherosclerotic plaque. Methods Totally 100 ACS patients were divided into observation group and control group (n=50 for each).Control group was received nitrates,angiotensin converting enzyme inhibitors and other conventional drugs,while observation group received Guanmaining tablet plus conventional drugs. Results The total efficiency of observation group was higher than control group (92.0％ vs. 66.0％,P＜0.01).No bleeding rate was observed more frequently in observation group compared with control group (84.0％ us.62.0％,P＜0.05).After 10 d treatment,the levels of BNP and hs-CRP of two groups were declined compared with before treatment (P＜0.01),and observation group decreased more significantly than control group ( P＜ 0.01). After 10 d treatment,the size of plaque plaque thickness and intima media thickness(IMT) were decreased,and observation group showed more obviously (P＜0.05).There were no adverse reaction in two groups. Conclusions Guanmaining tablet may be reliable effect in the treatment of ACS patients,through improving BNP and hs-CRP levels and inhibiting atheromatous plaque.
