Detection of brain energy metabolism changes by proton magnetic resonance spectroscopy in patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.0254-9026.2012.08.012
- VernacularTitle:磁共振氢质子波谱检查慢性阻塞性肺疾病患者大脑能量代谢异常的临床意义
- Author:
Wen WEN
;
Bin SUN
;
Deling LIU
;
Jia YE
;
Guoxiang LAI
- Publication Type:Journal Article
- Keywords:
Magnetic resonance spectroscopy;
Pulmonary disease,chronic obstructive;
Energy metabolism;
Brain
- From:
Chinese Journal of Geriatrics
2012;31(8):683-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the cerebral energy metabolism changes of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) through hydrogen magnetic resonance spectroscopy examination (1 HMRS ) and its relationship with partial pressure of oxygen / carbon dioxide tension.Methods Totally 13 cases of AECOPD patients and 10 cases of age-matched healthy people underwent HMRS examination.The ratios of n-acetyl-aspartate(NAA)/creatine(Cr),choline (Cho)/Cr,myo-inositol(MI)/Cr of parieto-temporal and occipital areas of brain were detected.Blood gas analysis were also used to detect partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2).Results NAA / Cr of parieto-temporal and occipital areas of brain (1.32±0.12,1.48±0.12) were lower in AECOPD group than those in control group (1.45±0.11,1.58±0.10) (P＜ 0.05),MI/Cr (0.23±0.07,0.30±0.11) were also decreased compared with control group (0.40±0.14,0.46±0.12) (P＜ 0.01),while Cho/Cr of parieto -temporal and occipital areas of brain between the AECOPD group and control group showed no significant difference (P＞0.05).NAA/Cr of parieto temporal and occipital areas of brain were positively correlated with PaO2 (r=0.46 and 0.44),and MI/Cr of these areas of brain were also positively related with PaO2 (r=0.63 and 0.50),but MI / Cr of parieto tempora was negatively correlated with PaCO2 (r =- 0.472). Conclusions Cerebral metabolite changes may occur in AECOPD patients,and this has relationship with hypoxia and carbon dioxide retention.
