Association of PITX3 polymorphism with Parkinson's disease in Chinese patients
10.3760/cma.j.issn.1674-6554.2012.07.008
- VernacularTitle:中国人群PITX3基因多态性与帕金森病的相关性
- Author:
Qingling LIN
;
Yanning CAI
;
Danhui WANG
;
Hui DING
;
Zhuqin GU
;
Jinghong MA
;
Biao CHEN
- Publication Type:Journal Article
- Keywords:
PITX3 gene;
Late-onset Parkinson's disease;
Early-onset Parkinson's disease;
Single nucleotide polymorphisns
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(7):598-600
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the relationship between polymorphism in the PITX3 gene and hereditary susceptibility of Parkinson's disease (PD). MethodsThree PITX3 single nucleotide polymorphisms ( SNPs ),including rs2281983,rs4919621 and rs3758549 were examined in 509 late-onset PD patients ( LOPD ),290 early-onset PD(EOPD) and 494 healthy controls.Genotyping was carried out in all subjects using a ligase detection reaction( LDR).ResultsAllele and genotype frequencies did not differ between the 799 PD patients and 494 controls ( P values of genotype were 0.494,0.343,0.951 ; P values of allele were 0.369,0.297,0.823 ),between 509 LOPD patients and 494 controls ( P values of genotype were 0.522,0.350,0.630 ; P values of allele were 0.413,0.328,0.571 ),between 290 EOPD patients and 494 controls ( P values of genotype were 0.499,0.492,0.552; P values of allele were 0.321,0.301,0.931 ),and between 509 LOPD and 290 EOPD patients ( P values of genotype were 0.577,0.710,0.127 ; P values of allele were 0.346,0.472,0.077 ) for all three SNPs (rs2281983,rs4919621 and rs3758549).There were no association petween the three PITX3 SNPs and PD.ConclusionThree PITX3 SNPs do not contribute to the risk of developing PD in Chinese population.
