Study on the relationship between uric acid and various cognitive functions in Alzheimer's disease

VernacularTitle:尿酸与阿尔茨海默病患者不同认知功能域的相关研究
Author: Ying ZHOU ; Hong TAN ; Aimin WANG
Publication Type:Journal Article
Keywords: Uric acid/blood; Alzheimer disease/metabolism/physiopathology; Cognition
From: Journal of Chinese Physician 2012;14(7):904-906
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between uric acid and various cognitive functions in Alzheimer's disease (AD).Methods A total of 46 patients with AD and 50 people without cognitive disorder were selected.Plasma uric acid,MOCA,and ADL were measured.Results The mean level of plasma uric acid was (217.93 ± 67.91 )μmol/L in ADs,and (337.02 ± 59.70) μmol/L in controls.The mean level of uric acid was significantly lower in the blood of patients with AD than control with a statistically significant difference ( t =9.142,P ＜0.01 ).Multiple regression analysis revealed that low uric acid,age,educated years,and hypertension were related to cognitive function( P ＜0.01,P ＜0.05 ).Partial correlation analysis revealed uric acid was significantly related to memory ( r =0.457,P =0.002),and attention ( r =0.398,P =0.008).Conclusions Low levels of uric acid may have influence on the occurrence and development of cognitive function impairment in AD.Uric acid may have more influence on the memory and attention in patients with AD.