Case control study of gastroesophageal reflux in patients with systemic sclerosis
10.3760/cma.j.issn.1007-7480.2012.07.005
- VernacularTitle:系统性硬化病患者发生胃食管反流症状的病例对照研究
- Author:
Xinjuan LIU
;
Mengtao LI
;
Zhuang TIAN
;
Dong XU
;
Yong HOU
;
Qian WANG
;
Qiuning SUN
;
Xiaofeng ZENG
- Publication Type:Journal Article
- Keywords:
Scleroderma,systemic;
Gastroesophageal reflux;
Hypertension,pulmonary
- From:
Chinese Journal of Rheumatology
2012;16(7):453-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the characteristics of gastroesophageal reflux (GER) and its clinical association with pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) patients.Methods Two hundred and five patients with SSc,who fulfilled the American College of Rheumatology criteria were consecutively recruited.GER was recognized in patients with symptom of heartburn or regurgitation.Demographic,clinical,and laboratory data were analyzed.A six minute walk test,pulmonary function test and modified Rodnan's skin score (mRSS) were also calculated for GER and non-GER groups.x2 test,Fisher's exact test and t-test were used for statistical analysis.Logistic regression test was used for the analysis of risk factors.Results There were 90 patients with GER among 205 patients,the prevalence of GER was 43.9％.The presence of PAH (23.3％ vs 9.6％),Raynaud's phenomenon (98.9％ vs 92.2％ ) and fingertip ulcers (56.7％vs 51.3％) were significantly higher in patients with GER than those without GER.There was no difference in autoantibody profile between GER patients and non-GER patients (P＞0.05).The New York Heart Association (NYHA) functional class of SSc-related GER was worse than patients without GER (P=0.015).Pulmonary function test showed that diffuse capacity (DLCO)％,forced vital capacity (FVC)％,and forced expiratory volume (FEV1)％ were lower and the FVC％/DLCO％ ratio was higher in patients with GER than non-GER (P＜0.05).GER was an independent risk factor of PAH in SSc patients (P=0.047,OR=3.41 ).Conclusion GER frequently occurs in SSc patients,SSc patients presenting with GER should be screened for PAH.Targeting the underlying vascular dysfunction might prevent not only PAH,but also GER in SSc patients.
