Effects of different doses of fentanyl on brain areas activated by pain: evidence from functional magnetic resonance imaging

VernacularTitle:不同剂量芬太尼对疼痛激活脑区的影响:功能性磁共振成像研究
Author: Sifang LIN ; Hongyu TAN ; Xiang QUAN ; Tiehu YE
Publication Type:Journal Article
Keywords: Fentanyl; Analgesia; Brain; Magnetic resonance imaging
From: Chinese Journal of Anesthesiology 2012;32(7):781-783
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of different doses of fentanyl on pain-activated brain areas as demonstrated by functional magnetic resonance imaging (fMRI) at 3.0 T.Methods Twenty healthy right-handed male volunteers aged 20-40 yr were randomly divided into 2 groups ( n =10 each); group F1 (fentanyl 1.0 μg/kg) and group F2 (fentanyl 1.5 μg/kg).Mechanical stimulation with von Frey filaments (vFFs,300 g) was delivered to left sole.The intensity of pain was assessed by VAS scores.fMRI was performed before and after fentanyl administration and the changes in the brain areas activated by pain were recorded.Results In group F1 ipsilateral (left) cingulate gyrus was activated after a bolus of fentanyl 1.0 μg/kg under stimulation with vFFs 300 g,while in group F2 bilateral cingulate gyrus and contralateral (right) insula were activated under vFFs stimulation after fentanyl 1.5 μg/kg.Conclusion Cingulate gyrus and insula may be the target brain areas of fentanyl analgesia.