Dynamic changes of endothelial progenitor cells and vascular endothelial growth factor in patients with myocardial infarction after percutaneous transluminal coronary intervention
10.3760/cma.j.issn.0254-9026.2012.07.004
- VernacularTitle:冠状动脉介入治疗心肌梗死患者外周血内皮祖细胞与血管内皮生长因子的变化
- Author:
Fangjiang LI
;
Tao XU
;
Yaling WANG
;
Guili YUAN
;
Jiuan ZHAO
;
Yue LI
;
Wencui YANG
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Angioplasty,transluminal,percutaneous coronary;
Endothelial cells;
Stem cells
- From:
Chinese Journal of Geriatrics
2012;31(7):555-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the dynamic changes of endothelial progenitor cells (EPC)and vascular endothelial growth factor (VEGF) in the patients with acute myocardial infarction (AMI)after percutaneous transluminal coronary intervention (PCI). Methods The level of VEGF before and after PCI in 50 cases with AMI were determined by fluorescence immunoassay and enzyme-linked immunosorbnent assay (ELISA),and the ratio of EPC in flood was checked by flow cytometry.Results The level of EPC was higher after PCI than before PCI [(4.15 ± 0.22)％ vs.(0.59 ±0.02) ％,P＜0.01],and there were positive correlations between EPC and number of coronary artery disease (r=0.45,P ＜ 0.05 ),coronary artery lesions ( r =0.76,P ＜ 0.01 ),left ventricular enddiastolic diameter (r=0.68,P＜0.01),ejection fraction (r=0.75,P＜0.01).The VEGF levels after PCI was increased [(506± 120)μg/L vs.(204±98)μg/L,P＜0.01],and its level was positively related with coronary lesions (r=0.66,P＜0.01),left ventricular ejection fraction(r=0.90,P＜0.01).There was association between rising rates of EPC and VEGF in a short time after PCI within 24 h period (r=0.56,P＜0.01). Conclusions The clinical efficacy and prognosis can be assessed by the changes of VEGF level and EPC ratio before and after PCI operation in AM1 patients.
