The establishment of the new formula for estimating glomerular filtration rate based on the serum creatinine
10.3760/cma.j.issn.1008-1372.2012.07.008
- VernacularTitle:以血清肌酐为变量估算肾小球滤过率新公式的创建
- Author:
Xixin WU
- Publication Type:Journal Article
- Keywords:
Technetium Tc 99m pentetate/blood;
Creatinine/blood;
Blood urea nitrogen;
Glomerular filtration rate;
China/ethnology
- From:
Journal of Chinese Physician
2012;14(7):889-892
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish an accurate,simple,safe,cheap,and logical new adult Chinese formula for measurement and calculation of glomerular filtration rate (eGFR).Methods GFRs from 136 cases of patients in hospital suffering from the different diseases were determined accurately using clearance rate of 99mTc-DTPA (Tc-GFR),and many clinical factors including serum creatinine (SCr) were determined simultaneously with routine method.The new equation for adult Chinese based on the SCr was obtained by the relationship and regression analysis for measurement and calculation GFR (SCrAC-eGFR).Tc-GFR from another 117 cases of patients were determined by the same method.SCr,and blood urea nitrogen were determined using routine method.eGFR were measured and calculated by 12 formulae such as SCrAC-eGFR,and USA DMS method.The relationship analysis and the contrast study from all data were performed.Results The equation was tenable,and the regression coefficient was significant ( P ＜ 0.01 ).eGFR from the six formulae for example SCrAC-eGFR,USA DMS method,Japan Picric method and so on could all give expression to GFR accurately at the some extent and the SCrAC-eGFR new formulae and USA DMS method formulae was more accurately than other and could take the place of Tc-GFR clinically.Conclusions The six formulae including SCrAC-eGFR,and USA DMS method were all accurate,simple,celer,safe,cheap,and rational methods for estimating GFR.It should apply and popularize clinically.
